Synthesis and antiinflammatory activity of 2-Methyl-5-[ω-phenylacyl] coumarans

VK Daukshas, PG Gaidyalis, OY Pyatrauskas…

Index: Daukshas, V. K.; Gaidyalis, P. G.; Pyatrauskas, O. Yu.; Udrenaite, E. B. Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 4 p. 246 - 248 Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 4 p. 29 - 30

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Abstract

Ketones II-IV were synthesized by the Friedel-Crafts reaction by acylation of 2- methylcoumaran (compound I) with the chloranhydrides of to-phenylalkane acids in the presence of anhydrous aluminum chloride. The structures of the newly synthesized compounds II-IV were confirmed by UV, IR, and PMR spectral data; the starting compound, I, has been described previously [2]. Increases in the number of methylene groups ...