Syntheses of Seven??Membered Rings: Ruthenium??Catalyzed Intramolecular [5+ 2] Cycloadditions

…, FD Toste, BG Steinmetz, C Koradin

Index: Trost, Barry M.; Shen, Hong C.; Horne, Daniel B.; Toste, F. Dean; Steinmetz, Bernhard G.; Koradin, Christopher Chemistry - A European Journal, 2005 , vol. 11, # 8 p. 2577 - 2590

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Citation Number: 97

Abstract

Abstract The Ru-catalyzed intramolecular [5+ 2] cycloaddition of cyclopropylenynes is investigated with respect to the regio-and diastereoselectivity as well as the functional group compatibility of the reaction. Evidence for the mechanism as occurring through a ruthenacyclopentene intermediate is elucidated from 1) the study of the diastereoselectivity of the cycloaddition; 2) the effect of variation of substituents on the regioselectivity of ...