A Novel Anti-Ischemic ATP-Sensitive Potassium Channel (K ATP) Opener without Vasorelaxation: N-(6-Aminobenzopyranyl)-N'-benzyl-N''-cyanoguanidine Analogue

S Yoo, KY Yi, S Lee, J Suh, N Kim, BH Lee…

Index: Atwal, Karnail S.; Ferrara, Francis N.; Ding, Charles Z.; Grover, Gary J.; Sleph, Paul G.; Dzwonczyk, Steven; Baird, Anne J.; Normandin, Diane E. Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 304 - 313

Full Text: HTML

Citation Number: 38

Abstract

... J. Med ... The epoxidation of 9 and 10 with Jacobsen's reagent [(S,S)-Mn(III)-salen complex] and NaOCl afforded two optically active epoxides 11 (2S ... The cyanoguanidine derivatives with N-aryl groups 19−22 were prepared by the treatment of amino alcohols 15 or 17 with N-cyano ...