The 3-substituted 2-indolinones have been designed as a novel class of tyrosine kinase inhibitors, which exhibit selectivity toward different receptor tyrosine kinases (RTKs)[1]. Investigations led to SU 5416, which is a potent and selective inhibitor of the vascular endothelial growth factor receptor (VEGF, Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization and growth of multiple tumor types [2]. In order to get a similar ...
