… .-2-selective ligands: synthesis and evaluation of N-[2-(3, 4-dichlorophenyl) ethyl]-N-methyl-2-(1-pyrrolidinyl) ethylamine-related polyamines at. sigma.-1 and. sigma.-2 …

BR de Costa, X He, C Dominguez, J Cutts…

Index: Costa, Brian R. de; He, Xiao-shu; Dominguez, Celia; Cutts, Janet; Williams, Wanda; Bowen, Wayne D. Journal of Medicinal Chemistry, 1994 , vol. 37, # 2 p. 314 - 321

Full Text: HTML

Citation Number: 30

Abstract

Investigation of the physiological and pharmacological role of a receptors is a relatively new area which has been facilitated by the development of high affinity and selective u receptor ligands.'The recent introduction of selective u receptor antagonists is further facilitating functional studies of this receptor. 2 Many different classes of drugslb ranging from steroids such as progesterone3 to neuroleptics such as haloperidol4 exhibit high affinity for u ...