Sulfonamide ligands attained through opening of saccharin derivatives

…, R Fryatt, C Wilson, S Woodward

Index: Robinson, Richard I.; Fryatt, Ross; Wilson, Claire; Woodward, Simon European Journal of Organic Chemistry, 2006 , # 19 p. 4483 - 4489

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Citation Number: 8

Abstract

Abstract Literature N-alkylsaccharins (saccharin-R 2) have been shown in some cases to be O-alkylated regioisomers by crystallography (3 structures). The genuine former species react with (S)-H 2 NCHR 1 CH 2 OH at 101 C in dioxane to provide 1, 2-C 6 H 4 (CONHCHR 1 CH 2 OH)(SO 2 NHR 2)[R 1= H, Me, iPr, Bn,(CH 2) 2 SMe; R 2= Bn, iPr, CHPh 2, CHMePh]. The (iPr, Bn) compound is crystallographically characterised. If both R 1 and R 2 are sterically ...