Synthesis and structure-activity relationship of (lactamylvinyl) cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci

I Heinze-Krauss, P Angehrn, P Guerry…

Index: Heinze-Krauss, Ingrid; Angehrn, Peter; Guerry, Philippe; Hebeisen, Paul; Hubschwerlen, Christian; Kompis, Ivan; Page, Malcolm G. P.; Richter, Hans G. F.; Runtz, Valerie; Stalder, Henri; Weiss, Urs; Wei, Chung-Chen Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1864 - 1871

Full Text: HTML

Citation Number: 25

Abstract

The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.