Abstract An efficient one-pot amination/lactamisation sequence for the preparation of 2- azabicyclo [2.2. 2] octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.
