5-Aminocoumarans: dual inhibitors of lipid peroxidation and dopamine release with protective effects against central nervous system trauma and ischemia

S Ohkawa, K Fukatsu, S Miki, T Hashimoto…

Index: Ohkawa, Shigenori; Fukatsu, Kohji; Miki, Shokyo; Hashimoto, Tadatoshi; Sakamoto, Junko; Doi, Takayuki; Nagai, Yasuo; Aono, Tetsuya Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 559 - 573

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Citation Number: 53

Abstract

A series of 2, 3-dihydro-5-benzofuranamines (5-aminocoumarans) were developed for the treatment of traumatic and ischemic central nervous system (CNS) injury. Compounds within this class were extremely effective inhibitors of lipid peroxidation in vitro and antagonized excitatory behavior coupled with peroxidative injury induced by spinal intrathecal injection of FeCl2 (mouse-FeCl2-it assay) in vivo. Selected compounds were tested for antagonistic ...