Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities

N Ueberschaar, Z Xu, K Scherlach…

Index: Kloss, Florian; Koehn, Uwe; Jahn, Burkhard O.; Hager, Martin D.; Goerls, Helmar; Schubert, Ulrich S. Chemistry - An Asian Journal, 2011 , vol. 6, # 10 p. 2816 - 2824

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Citation Number: 15

Abstract

... However, the chartreusin chemotype could be restored by coexpressing the chaABC gene cassette on a replicative plasmid (pKJ01).(27) In stark contrast, the strain ... The main challenge associated with this step appeared to be the lactonization of the o-coumaric ester and ...