2-Amino-4-piperazinobutyric Acid (I).-To a solution of 6.9 g.(0.173 mole) of potassium in 150 ml. of dry t-butyl alcohol6 was added 31 g.(0.143 mole) of ethyl a-acetamidomalonate, the temperature being maintained just above the freezing point of the solvent. While the resulting solution was stirred, a suspension of 40.5 g.(0.157 mole) of 1-P-chloroethyl-4- carbethoxypiperazine in 150 ml. of dry t-butyl alcohol and a solution of 6.9 g.(0.17 mole) of ...
