Bisquinolines. 1. N, N-bis (7-chloroquinolin-4-yl) alkanediamines with potential against chloroquine-resistant malaria

…, SL Andersen, L Gerena, WK Milhous

Index: Vennerstrom, Jonathan L.; Ellis, William Y.; Ager, Arba L.; Andersen, Steven L.; Gerena, Lucia; Milhous, Wilbur K. Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2129 - 2134

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Citation Number: 121

Abstract

CI chloroquine mechanism (8) of action of CQ and mechanism (s) of resistance to chloroquine are incompletely understood, 3 work by Martin et alS4 demonstrates that verapamil effectively reverses resistance to CQ. Verapamil and other “resistance modulator” drugs which reverse CQ resistance are believed to act by a blockade or inhibition of a putative drugtransporter membrane protein (P-glycoprotein); this protein normally allows ...