The Journal of Organic Chemistry

Carbonyl-protected. beta.-lithio aldehydes and ketones via reductive lithiation. A general preparative method for remarkably versatile homoenolate equivalents

JP Cherkauskas, T Cohen

Index: Cherkauskas, John P.; Cohen, Theodore Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 6 - 8

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Citation Number: 67

Abstract

Summary: A general procedure for producing homoenolate equivalents consists of reductive lithiation, induced by 4, 4'-di-tert-butylbiphenylide, of carbonyl-protected@-(phenylthio) carbonyl compounds prepared in turn by thiophenol addition to enones or the alkylation of silyl enol ethers by a-chlorothioethers.