Transition metals in organic synthesis-Part 83#: Synthesis and pharmacological potential of carbazoles

TA Choi, R Czerwonka, R Forke, A Jäger…

Index: Choi, Taylor A.; Czerwonka, Regina; Forke, Ronny; Jaeger, Anne; Knoell, Jan; Krahl, Micha P.; Krause, Tilo; Reddy, Kethiri R.; Franzblau, Scott G.; Knoelker, Hans-Joachim Medicinal Chemistry Research, 2008 , vol. 17, # 2-7 p. 374 - 385

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Citation Number: 66

Abstract

Abstract A series of carbazole derivatives with promising pharmacological properties has been prepared using either an iron-mediated or a palladium-catalyzed synthetic approach. The carbazole alkaloids carbazoquinocin C, carbazomadurin A and B, epocarbazolin A and B, neocarazostatin B, and carquinostatin A are antioxidants acting as free-radical scavengers. Thus, they represent potential lead compounds for the development of novel ...