Modular Total Synthesis of Rhizopodin: A Highly Potent G??Actin Dimerizing Macrolide

…, S Rudolph, D Herkommer, J Troendlin…

Index: Kretschmer, Manuel; Dieckmann, Michael; Li, Pengfei; Rudolph, Sven; Herkommer, Daniel; Troendlin, Johannes; Menche, Dirk Chemistry - A European Journal, 2013 , vol. 19, # 47 p. 15993 - 16018

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Citation Number: 21

Abstract

Abstract A highly convergent total synthesis of the potent polyketide macrolide rhizopodin has been achieved in 29 steps by employing a concise strategy that exploits the molecule′ s C 2 symmetry. Notable features of this convergent approach include a rapid assembly of the macrocycle through a site-directed sequential cross-coupling strategy and the bidirectional attachment of the side chains by means of Horner–Wadsworth–Emmons ( ...