Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties

…, GM Olins, EG McMahon, WC Hutton

Index: Bovy, P. R.; Collins, J. T.; Olins, G. M.; McMahon, E. G.; Hutton, W. C. Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2410 - 2414

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Citation Number: 25

Abstract

Figure 2. Expansion of the NOESY stacked-plot spectrum showing the cross-peaks for the H- 7 protons of both isomers. The cross-relaxation with the hydmxymethyl protons (H-5) establishes the regiochemistry of the substituents 4, 5 on the imidazolyl ring of isomer 9. This particular cross peak is missing for isomer 8, while all other cross-relaxation for H-7 are very similar. The cross-peaks are anti-phase with respect to the diagonal peak at 6.4 ppm as in ...