The reactivation of a lyophilized preparation of diethylphosphoryl (DEP) chymotrypsin by approximately forty nucleophilic agents (oximes and hydroxamic acids) was examined, using a rapid colorimetric assay for chymotrypsin. The! iydroxamic acids tested were synthesized by the usual methods as well as by two new synthetic techniques. With the exception of three compounds, all of the nucleophilic agents possessed activities which ...
