New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

…, TP Jerussi, MJ Benvenga, T Spaulding

Index: Bagley; Thomas; Rudo; Spencer; Doorley; Ossipov; Jerussi; Benvenga; Spaulding Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 827 - 841

Full Text: HTML

Citation Number: 26

Abstract

A series of new 1-(heterocyclyalkyl)-4-(propionanilido)-4-piperidinyl methyl esters and methylene methyl ethers have been synthesized and pharmacologically evaluated. In the mouse hot-plate test, the majority of compounds exhibited an analgesia (EDm< 1 mg/kg) superior to that of morphine. These studies revealed a pharmacological accommodation for many more structurally diverse and far bulkier aromatic ring systems than the ...