Cascade Palladium??Catalyzed Direct Intramolecular Arylation/Alkene Isomerization Sequences: Synthesis of Indoles and Benzofurans

M Yagoubi, ACF Cruz, PL Nichols…

Index: Yagoubi, Myriam; Cruz, Ana C. F.; Nichols, Paula L.; Elliott, Richard L.; Willis, Michael C. Angewandte Chemie - International Edition, 2010 , vol. 49, # 43 p. 7958 - 7962

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Citation Number: 38

Abstract

The development of metal-catalyzed direct arylation reactions between activated aromatic rings, most usually aryl halides, and a non-activated aromatic coupling partner has had a tremendous impact on the synthesis of biaryl carbon–carbon bonds.[1–3] The direct functionalization of heteroaromatic molecules features prominently among these reactions.[4] Although less general, variations of these methods to include the direct union ...