A general synthesis approach to pyrroloquinolizidines (3, 4, 5, 5a, 6, 7, 8-heptahydropyrrolo [2, 1, 5-de] quinolizines) via a münchnone 1, 3-dipolar cycloaddition is reported. The approach was applied to the synthesis of an unnatural pyrroloquinolizidine homologue of myrmicarin 215B.