Novel symmetrical ureas as modulators of protein arginine methyl transferases

…, P García-Domínguez, R Álvarez, ÁR de Lera

Index: Fontan, Noelia; Garcia-Dominguez, Patricia; Alvarez, Rosana; De Lera, Angel R. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 2056 - 2067

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Citation Number: 9

Abstract

Methylation of histone arginine residues is an epigenetic mark related to gene expression that is implicated in a variety of biological processes and can be reversed by small-molecule modulators of protein arginine methyltransferases (PRMTs). A series of symmetrical ureas, designed as analogues of the known PRMT1 inhibitor AMI-1 have been synthesized using Pd-catalyzed Ar–N amide bond formation processes or carbonylation reactions as key ...