Enantioselective bioreduction of (E)-1-phenyl-1, 2-alkanedione 2-(O-methyloxime)

OC Kreutz, RCM Segura, JAR Rodrigues…

Index: Kreutz, Olyr C.; Segura, Renata C. M.; Rodrigues, J. Augusto R.; Moran, Paulo J. S. Tetrahedron Asymmetry, 2000 , vol. 11, # 10 p. 2107 - 2115

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Citation Number: 13

Abstract

The baker's yeast reduction of (E)-1-phenyl-1, 2-alkanedione 2-(O-methyloxime), PhC (O) C (NOMe) R (R= Me, Et, n-Pr, n-Bu), gave the corresponding optically active alcohols PhCH2OHC (NOMe) R in 88–99% enantiomeric excess and 48–75% chemical yield. The ...