Tetrahedron letters

Solvent-free microwave synthesis of 4-hydroxy-3-phenylquinolin-2 (1H)-ones and variants using activated arylmalonates

A Rivkin, B Adams

Index: Rivkin, Alexey; Adams, Bruce Tetrahedron Letters, 2006 , vol. 47, # 14 p. 2395 - 2398

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Citation Number: 26

Abstract

In an ongoing medicinal chemistry program we required the synthesis of 4-hydroxy-3-phenylquinolin -2(1H)-ones and related variants. One of the methods we used to rapidly prepare these compounds was a microwave reaction that was recently reported by Lange et al. 5b An example of this microwave reaction is shown in Eq. 1. It was reported that irradiation of a mixture of 4-methoxyaniline (1) and diethyl-2-phenylmalonate (2) in a open reaction vessel afforded quinolinone 3 in ...