e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and structure-activity relationships of 6-substituted 2', 3'-dideoxypurine nucleosides as potential anti-human immunodeficiency virus agents

…, LS Jeong, SK Ahn, B Doboszewski…

Index: Chu, Chung K.; Ullas, Giliyar V.; Jeong, Lak S.; Ahn, Soon K.; Doboszewski, Bogdan; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1553 - 1561

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Citation Number: 52

Abstract

In order to study the structure-activity relationships of 2', 3'-dideoxypurine nucleosides as potential anti-HIV agents, various 6-substituted purine analogues have been synthesized and examined in virus-infected and uninfected human peripheral blood mononuclear cells. M-methyl-2', 3'-dideoxyadenosine (D2MeA, 7a) was initially synthesized from adenosine via 2', 3'-0-bisxanthate 3. As extension of this reaction to other N6-substituted compounds ...

N/A Structure

~%

[(2S,5R)-5-[6-(methylamino)purin-9-yl]-2,5-dihydrofuran-2-yl]methanol Structure

[(2S,5R)-5-[6-(...

N/A Structure

~%

[(2S,5R)-5-[6-(methylamino)purin-9-yl]-2,5-dihydrofuran-2-yl]methanol Structure

[(2S,5R)-5-[6-(...

9-(5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-D-ribofuranosyl)-6-chloropurine Structure

9-(5-O-(tert-bu...

~37%

N/A Structure

(2S,5R)-5-(6-Chloro-9H-purine-9-yl)tetrahydro-2-furanmethanol Structure

(2S,5R)-5-(6-Ch...

N6-benzyl-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyadenosine Structure

N6-benzyl-5'-O-...

~47%

N/A Structure

[(2S,5R)-5-[6-(benzylamino)purin-9-yl]oxolan-2-yl]methanol Structure

[(2S,5R)-5-[6-(...

9-(5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-D-ribofuranosyl)-6-chloropurine Structure

9-(5-O-(tert-bu...

~%

[(2S,5R)-5-[6-(benzylamino)purin-9-yl]oxolan-2-yl]methanol Structure

[(2S,5R)-5-[6-(...

Benzylamine Structure

~%

[(2S,5R)-5-[6-(benzylamino)purin-9-yl]oxolan-2-yl]methanol Structure

[(2S,5R)-5-[6-(...

A highly stereoselective synthesis of anti-HIV 2', 3'-dideox...

[Beach, J. Warren; Kim, Hea O.; Jeong, Lak S.; Nampalli, Satyanarayana; Islam, Qamrul; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3887 - 3894]

A highly stereoselective synthesis of anti-HIV 2', 3'-dideox...

[Beach, J. Warren; Kim, Hea O.; Jeong, Lak S.; Nampalli, Satyanarayana; Islam, Qamrul; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3887 - 3894]

A highly stereoselective synthesis of anti-HIV 2', 3'-dideox...

[Beach, J. Warren; Kim, Hea O.; Jeong, Lak S.; Nampalli, Satyanarayana; Islam, Qamrul; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3887 - 3894]

A highly stereoselective synthesis of anti-HIV 2', 3'-dideox...

[Beach, J. Warren; Kim, Hea O.; Jeong, Lak S.; Nampalli, Satyanarayana; Islam, Qamrul; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3887 - 3894]

A highly stereoselective synthesis of anti-HIV 2', 3'-dideox...

[Beach, J. Warren; Kim, Hea O.; Jeong, Lak S.; Nampalli, Satyanarayana; Islam, Qamrul; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3887 - 3894]