Oxidation of Unactivated Primary Aliphatic Amines Catalyzed by an Electrogenerated 3, 4??Azaquinone Species: A Small??Molecule Mimic of Amine Oxidases

M Largeron, A Neudorffer…

Index: Largeron, Martine; Neudorffer, Anne; Fleury, Maurice-Bernard Angewandte Chemie - International Edition, 2003 , vol. 42, # 9 p. 1026 - 1029

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Citation Number: 41

Abstract

The copper amine oxidases are ubiquitous enzymes that occur in bacteria, yeast, plants, and mammals. These enzymes catalyze the two-electron oxidative deamination of a primary amine to produce the corresponding aldehyde and ammonia, with subsequent two-electron reduction of dioxygen to hydrogen peroxide. To carry out this reaction, copper amine oxidases, which belong to the new class of proteins designated quinoproteins, contain two ...