Practical asymmetric catalytic synthesis of spiroketals and chiral diphosphine ligands

X Wang, P Guo, X Wang, Z Wang…

Index: Wang, Xiaoming; Wang, Xubin; Guo, Peihua; Wang, Zheng; Ding, Kuiling Advanced Synthesis and Catalysis, 2013 , vol. 355, # 14-15 p. 2900 - 2907

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Citation Number: 19

Abstract

Abstract: A practical procedure has been developed for efficient synthesis of chiral aromatic spiroketals and the relevant diphosphine ligands. The procedure includes first asymmetric hydrogenation of readily available α, αо-bis (2-benzyloxyarylidene) ketones catalyzed by the Ir (I)/SpinPHOX (S, S)-1a (0.5–1 mol%) and subsequent hydrogenative deprotection of the resultant benzyl ethers catalyzed by palladium on carbon (Pd/C), as well as simultaneous ...