Recent reports1-8 indicate that certain alkamine ethers, particularly 8-dimethylaminoethyl benzhydryl ether hydrochloride, possess a high order of antihistaminic activity. Antispasmodic properties have also been claimed for compounds of this general~ tructure.~ In view of the diversified activities of these alkamine ethers, an investigation of related ethers of this type was undertaken. The compounds listed in Table I were prepared either by ...
