Synthesis of Some Functionalized Phosphinocarboxylic Acids

JA Van Doorn, N Meijboom

Index: van Doorn, J. A.; Meijboom, N. Phosphorus, Sulfur and Silicon and the Related Elements, 1989 , vol. 42, p. 211 - 222

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Citation Number: 9

Abstract

Abstract Various functionalized phosphinocarboxylic acids have been prepared by a number of complementary methods. Reactions of relatively electron-poor secondary phosphides with electron-rich halocarboxylates in liquid ammonia give high yields of phosphinocarboxylates. The substitution reaction may proceed by a classical SN 2 mechanism or by an SN rad mechanism. Reduction of the carboxylate can be a ...