Synthesis and pharmacological characterization of new silicon-based W84-type allosteric modulators for ligand binding to muscarinic M 2 receptors

S Duda-Johner, JO Daiß, K Mohr, R Tacke

Index: Duda-Johner, Seraina; Daiss, Juergen O.; Mohr, Klaus; Tacke, Reinhold Journal of Organometallic Chemistry, 2003 , vol. 686, # 1-2 p. 75 - 83

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Citation Number: 12

Abstract

The silicon-based allosteric modulators of ligand binding to muscarinic acetylcholine receptors [R1(CH2) 3 SiMe2(CH2) 5 NMe2(CH2) 3 R1] Br (3),[R2(CH2) 3 SiMe2(CH2) 5 NMe2(CH2) 3 R2] Br (4),[R1(CH2) 3 SiMe2(CH2) 5 NMe2(CH2) 3 R2] Br (5), and [R2(CH2) 3 SiMe2(CH2) 5 NMe2(CH2) 3 R1] Br (6)(R1= phthalimido; R2= 1, 8-naphthalimido) were synthesized, starting from ...