Syntheses of Phospholipids Containing 2-Nitrobenzyl Ester Moieties at the Terminals of Alkyl Chains and Properties of Photodegradable Liposomes from the Lipids.

K Yamaguchi, Y Tsuda, T Shimakage…

Index: Yamaguchi, Kazuo; Tsuda, Yoshihiro; Shimakage, Taka-Aki; Kusumi, Akihiro Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 8 p. 1923 - 1929

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Citation Number: 13

Abstract

Phospholipid 1a bearing 2-nitrobenzyl ester moieties as a photocleavable group at the terminal of alkyl chains was synthesized from the corresponding terminal carboxy-bearing phospholipid 2 by the reaction with 2-nitrophenyl-substituted diazomethane. Phospholipid, 1b bearing α-methyl-2-nitrobenzyl group, 1c bearing 4, 5-dimethoxy-2-nitrobenzyl group, and 1d bearing α-methyl-4, 5-dimethoxy-2-nitrobenzyl group were similarly synthesized ...