Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells

CK Chu, RF Schinazi, MK Ahn, GV Ullas…

Index: Chu, Chung K.; Schinazi, Raymond F.; Ahn, Moon K.; Ullas, Giliyar V.; Gu, Zi P. Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 612 - 617

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Citation Number: 145

Abstract

The structure-activity relationships of several pyrimidine nucleosides related to 3'-azido-3'- deoxythymidine(AZT) were determined in human immunodeficiency virus type 1 (HIV-1) infected human peripheral blood mononuclear cells. These studies indicated that nucleosides with a 3'-azido group on the sugar ring exhibited the most potent antiviral activity. Substitution at C-5 with H, CH, and C2H5 produced derivatives with the highest ...

~60%

~81%

Antimycobacterial activities of 5-alkyl (or halo)-3′-substit...

[Srivastav, Naveen C.; Shakya, Neeraj; Bhavanam, Sudha; Agrawal, Amogh; Tse, Chris; Desroches, Nancy; Kunimoto, Dennis Y.; Kumar, Rakesh Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1091 - 1094]