Total synthesis of (.+-.)-ginkgolide B

EJ Corey, MC Kang, MC Desai, AK Ghosh…

Index: Corey, E. J.; Kang, Myung-chol; Desai, Manoj C.; Ghosh, Arun K.; Houpis, Ioannis N. Journal of the American Chemical Society, 1988 , vol. 110, # 2 p. 649 - 651

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Citation Number: 180

Abstract

11 12 isolation and silica gel chromatography (SGC) an 80% yield of enol triflate 5. A solution of 5 and Pd (PPh3),(5.7 mol%) in benzene was stirred at 16 OC for 15 min and then treated successively with a benzene solution of acetylenic OB0 ester 6"(1 equiv), n- propylamine (2.3 equiv), and 0.5 equiv of cuprous iodide, all at 16" C to give after 4 h at 16 OC, extractive isolation and SGC 76-84% of the coupling product 7 (2: l mixture of ...