The first total synthesis and structural determination of TMC-264

K Tatsuta, A Furuyama, T Yano, Y Suzuki, T Ogura…

Index: Tatsuta, Kuniaki; Furuyama, Akiho; Yano, Tomoe; Suzuki, Yasuaki; Ogura, Takashi; Hosokawa, Seijiro Tetrahedron Letters, 2008 , vol. 49, # 25 p. 4036 - 4039

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Citation Number: 8

Abstract

TMC-264 (1) was isolated as an inhibitor of IL-4 signaling from the fermentation broth of a fungus Phoma sp. TC 1674 by Tanabe Seiyaku group in 2003. 1 This compound has been found to inhibit selectively both tyrosine phosphorylation of STAT6 and the complex formation of phosphorylated STAT6 with its recognition sequence. TMC-264 has been expected as an antiallergic agent. 1 and 2 The structure of TMC-264 was elucidated to be the tricyclic structure including ...