Highly enantioselective hydrogenation of α-arylmethylene cycloalkanones catalyzed by iridium complexes of chiral spiro aminophosphine ligands

JB Xie, JH Xie, XY Liu, WL Kong, S Li…

Index: Xie, Jian-Bo; Xie, Jian-Hua; Liu, Xiao-Yan; Kong, Wei-Ling; Li, Shen; Zhou, Qi-Lin Journal of the American Chemical Society, 2010 , vol. 132, # 13 p. 4538 - 4539

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Citation Number: 47

Abstract

The highly efficient asymmetric hydrogenation of α-arylmethylene cycloalkanones catalyzed by Ir-complexes of chiral spiro aminophosphine ligands was developed, providing chiral exo- cyclic allylic alcohols at high yields with excellent enantioselectivities (up to 97% ee) and high turnover numbers (S/C up to 10,000). This new reaction provided an efficient method for the synthesis of the key intermediate of the active form of the anti-inflammatory ...