8-Methylureido-4, 5-dihydro-4-oxo-10H-imidazo [1, 2-a] indeno-[1, 2-e] pyrazines: highly potent in vivo AMPA antagonists

S Mignani, GA Bohme, A Boireau, M Cheve…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 6 p. 591 - 596

Full Text: HTML

Citation Number: 12

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 4 In an effort to increase the potency of 1, chemical optimization was performed, and we describe herein the synthesis and the structure–activity relationships of the resulting substituted imidazo[1,2-a]indeno[1,2-e]pyrazine-4-ones 2a–y ...