… , and biological activity in terms of an assessment of these systems to inhibit the induction of ornithine decarboxylase activity and to induce terminal differentiation of …

LW Spruce, SN Rajadhyaksha, KD Berlin…

Index: Spruce, Lyle W.; Rajadhyaksha, Shirish N.; Berlin, K. Darrell; Gale, Jonathan B.; Miranda, Edgar T.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1474 - 1482

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Citation Number: 22

Abstract

NMR analyses was completed for these heterocycles. The biological activity of these heteroarotinoids was assayed by either the suppression of the 12-0-tetradecanoylphorbol 13-acetate (TPA) induced synthesis of ornithine decarboxylase (ODC) in mouse skin or the induction of differentiation of human (HL-60) promyelocytic cells. In the ODC assay, systems la-c exhibited strong activity (within 10% of or less than the control) whereas alcohols 2b ...

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