Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles

…, P Lohan, DK Aneja, GK Gupta, D Kaushik…

Index: Kumar, Ajay; Lohan, Poonam; Aneja, Deepak K.; Gupta, Girish Kumar; Kaushik, Dhirender; Prakash, Om European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 81 - 89

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Citation Number: 19

Abstract

Two series of compounds namely, 4-aryl/heteroaryl hydrazino-3-acetyl-6-methyl-2H-pyran-2- ones (4a–4j) and pyrano [4, 3-c] pyrazoles (6a–6e and 6g) were synthesized starting from 3- acetyl-4-chloro-6-methyl-2H-pyran-2-one (2). Estimation of pharmacotherapeutic potential, possible molecular mechanism of action, toxic/side effects and interaction with drug- metabolizing enzymes were made for the synthesized compounds on the basis of ...