Synthesis and antitumor activity of N-terminal proline-containing peptide-(chloroethyl) nitrosoureas

H Suli-Vargha, A Jeney, K Lapis…

Index: Suli-Vargha; Jeney; Lapis; Medzihradszky Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 583 - 586

Full Text: HTML

Citation Number: 13

Abstract

The N~-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of H-Pro-Lys (X)-Pro-Val-NH,(X: tert- butyloxycarbonyl, formyl,(2-chloroethyl) nitrosocarbamoyl) were synthesized. It was found that the bis-substitution of the urea N3 in these derivatives does not decrease the antitumor activity influenced mainly by the nature of the carrier molecule as a whole.