Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation

JP Lajiness, WM Robertson, I Dunwiddie…

Index: Greck, Christine; Bischoff, Laurent; Girard, Anne; Hajicek, Josef; Genet, Jean-Pierre Bulletin de la Societe Chimique de France, 1994 , vol. 131, # 4 p. 429 - 433

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Citation Number: 23

Abstract

... Volume: Page: ... by a 10-step sequence in 28% overall yield.(19) Deprotonation of 11 with LiHMDS in ether:1,4-dioxane (1:1) at 0 °C, followed by the addition of TsONHBoc(20) and maintaining the reaction mixture at room temperature (0.1 M) for 4 h resulted in ...