Synthesis of the novel sarcosine and proline (FK-525) analogs of FK-506: rearrangement of the allylic ester system

D Askin, RA Reamer, D Joe, RP Volante…

Index: Askin, D.; Reamer, R. A.; Joe, Daisy; Volante, R. P.; Shinkai, I. Journal of Organic Chemistry, 1990 , vol. 55, # 20 p. 5448 - 5450

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Citation Number: 14

Abstract

In conclusion, we have shown that the olefination of alkylidenemalonates 1 by 1,l-dimetalloalkanes 2 can ac- commodate a variety of functional groups and afford PO- lyfunctional olefins 3 with fair to excellent 2 stereoselec- tivities. Further studies are currently underway in our laboratories. ... Foundation (Grant CHE-8818704) and the donors of the Petroleum Research Fund, administered by the American Chemical Society, for support of this research.