Synthesis and transformations of 4, 5??dihydro??1, 4??benzothiazepin??3 (2H)??one derivatives

J Szabó, L Fodor, Á Katócs, G Bernáth…

Index: Szabo, Janos; Fodor, Lajos; Katocs, Agnes; Bernath, Gabor; Sohar, Pal Chemische Berichte, 1986 , vol. 119, # 9 p. 2904 - 2913

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Citation Number: 8

Abstract

Abstract The attempted cyclization of S-(3, 4-dimethoxyphenyl)-N-(hydroxymethyl) thioglycolamide (6) with phosphoryl chloride gave, instead of the expected benzothiazepinone 7e,(3, 4-dimethoxyphenylthio) acetonitrile (8). The product of ring closure of N-[[2-(benzoylthio)-4, 5-dimethoxyphenyl] methyl]-2-chloroacetamide (11) with sodium ethoxide was 4, 5-dihydro-7, 8-dimethoxy-1, 4-benzothiazepin-3 (2H)-one (7e). ...