An approach to the design of potential combined antithrombotic-antihypertensive agents is described. A series of 1, 4-dihydropyridines bearing a lH-imidazol-l-yl or pyrid-3-yl substituted side chain in the 2-position were synthesized and tested for antihypertensive activity in spontaneously hypertensive rats and for inhibition of TXAz synthetase in rabbit platelets, in vitro. 1, 4Dihy&e2-(lH-imidazol-1-ylmethyl)~ methyl-4-(3-~~ ophenyl) pyridin~ ...
