Copper??Catalyzed Enantioselective Conjugate Addition of Dialkylzinc Reagents to α′??Oxy Enones

…, JM Odriozola, M Oiarbide, J Razkin…

Index: Garcia, Jesus M.; Gonzalez, Alberto; Kardak, Bharat G.; Odriozola, Jose M.; Oiarbide, Mikel; Razkin, Jesus; Palomo, Claudio Chemistry - A European Journal, 2008 , vol. 14, # 29 p. 8768 - 8771

Full Text: HTML

Citation Number: 14

Abstract

The Cu-catalyzed asymmetric conjugate addition (ACA) of organozinc reagents to α, β- unsaturated carbonyl groups constitutes a CÀC bond forming reaction of great synthetic value because of its mildness and broad functional group tolerance.[1, 2] When using cyclic α, β-unsaturated carbonyls as acceptors, the stereocontrol of the reaction is often remarkable.[3] However, the acyclic counterparts generally give poor results,[4] likely ...