Biocatalytic Michael??Type Additions of Acetaldehyde to Nitroolefins with the Proline??Based Enzyme 4??Oxalocrotonate Tautomerase Yielding Enantioenriched γ?? …

…, PG Tepper, P de Haan, E Zandvoort…

Index: Geertsema, Edzard M.; Miao, Yufeng; Tepper, Pieter G.; Dehaan, Pim; Zandvoort, Ellen; Poelarends, Gerrit J. Chemistry - A European Journal, 2013 , vol. 19, # 43 p. 14407 - 14410

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Citation Number: 21

Abstract

Edzard M. Geertsema, Yufeng Miao, Pieter G. Tepper, Pim de Haan, Ellen Zandvoort, and Gerrit J. Poelarends*[a] g-Nitroaldehydes are versatile and practical precursors for chiral g- aminobutyric acids (GABAs). In particular, prominent GABA analogues, such as marketed pharmaceuticals phenibut [1](GABAB receptor agonist, anxiolytic), pregabalin [2](anticonvulsant), baclofen [3](GABAB receptor agonist, anti-alcoholism), and rolipram [4 ...