Abstract Successive transformations of 5-(2, 5-dimethylphenyl)-1, 2-oxazole-3-carbonitrile, including Curtius rearrangement, led to the formation of 5-(2, 5-dimethylphenyl)-1, 2-oxazol- 3-amine. Sulfonamides and urea derivative containing 5-(2, 5-dimethylphenyl) isoxazole fragments were synthesized.