Antitumor agents: diazomethyl ketone and chloromethyl ketone analogs prepared from N-tosyl amino acids

Z Sajadi, M Kashani, LJ Loeffler…

Index: Sajadi; Kashani; Loeffler; Hall Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 275 - 278

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Citation Number: 11

Abstract

Diazomethyl ketone and chloromethyl ketone analogues prepared from N-tosyl amino acids have been synthesized and tested for antitumor activity in Ehrlich ascites carcinoma and P- 388 lymphocytic leukemia screens in mice. The N-tosyl chloromethyl ketone analogues prepared from glycine, L-alanine,@-alanine, L-valine, and 6-(N-tosylamino) caproic acid were the most potent antineoplastic agents in the Ehrlich ascites carcinoma screen. The N ...