Cytotoxic effect of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in Pt II complexes on human carcinoma cell lines: A comparative study with cisplatin

N Ferri, S Cazzaniga, L Mazzarella, G Curigliano…

Index: Ferri, Nicola; Cazzaniga, Stefano; Mazzarella, Luca; Curigliano, Giuseppe; Lucchini, Giorgio; Zerla, Daniele; Gandolfi, Raffaella; Facchetti, Giorgio; Pellizzoni, Michela; Rimoldi, Isabella Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2379 - 2386

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Citation Number: 7

Abstract

The synthesis and pharmacological characterisation of (1-methyl-1H-imidazol-2-yl)- methanamine and its derivatives in PtII complexes are described. Six out of eleven new PtII complexes showed a significant cytotoxic effect on NCI-H460 lung cancer cell line with EC50 values between 1.1 and 0.115 mM, determined by MTT assay. Compound Pt-4a showed a particularly more potent cytotoxic effect than the previously described PtII ...