Development of a practical synthesis of a purine nucleoside phosphorylase inhibitor: BCX-4208

VP Kamath, JJ Juarez-Brambila…

Index: Organic Process Research and Development, , vol. 13, # 5 p. 928 - 932

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Citation Number: 24

Abstract

... Organic Process Research & Development. ... procedures suffered from either low yields or purification challenges and were unlikely to provide scalable processes.(8-10 ... API in water/ethanol mixture furnished crystals of BCX-4208 (1) in yields comparable to the kilo-scale process. ...