Application of a Supramolecular??Ligand Library for the Automated Search for Catalysts for the Asymmetric Hydrogenation of Industrially Relevant Substrates

J Meeuwissen, M Kuil, AM van der Burg…

Index: Meeuwissen, Jurjen; Kuil, Mark; Van Der Burg, Alida M.; Sandee, Albertus J.; Reek, Joost N. H. Chemistry - A European Journal, 2009 , vol. 15, # 39 p. 10272 - 10279

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Citation Number: 54

Abstract

Abstract A procedure is described for the automated screening and lead optimization of a supramolecular-ligand library for the rhodium-catalyzed asymmetric hydrogenation of five challenging substrates relevant to industry. Each catalyst is (self-) assembled from two urea- functionalized ligands and a transition-metal center through hydrogen-bonding interactions. The modular ligand structure consists of three distinctive fragments: the urea binding motif, ...