C-5 modified nucleosides: Direct insertion of alkynyl-thio functionality in pyrimidines

…, A Roychowdhury, SA Benner

Index: Held, Heike A.; Roychowdhury, Abhijit; Benner, Steven A. Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 4 p. 391 - 404

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Citation Number: 17

Abstract

It has been two decades since the enzymic incorporation of functionalized nucleotides was first suggested to be useful to tag DNA with functionality that it did not intrinsically carry.[1]1. Langer , PR , Waldrop , AA and Ward , DC 1981. Enzymic synthesis of biotin-labeled polynucleotides: Novel nucleic acid affinity probes. Proc. Natl. Acad. Sci. USA-Biol. Sci., 78: 6633–6637. [CrossRef], [PubMed], [Web of Science ®] View all references [2]2. Bergstrom ...